Stage III breast cancer is characterized by one of the following:
- A primary cancer that measures less than 5 cm (2 inches) in size and causes axillary (underarm) lymph nodes to be attached to each other or other structures
- A primary cancer that is greater than 5 cm (2 inches) in size and involves axillary lymph nodes
- A primary cancer that is attached to the chest wall or skin
Breast cancer that has spread to the lymph nodes is commonly referred to as node-positive disease.
Effective treatment of stage III breast cancer requires both local and systemic therapy. Local therapy consists of surgery and/or radiation and is directed at destroying any cancer cells in or near the breast. Systemic therapy is directed at destroying cancer cells throughout the body, and may include chemotherapy, hormonal therapy, or biological therapy. Systemic therapy may be administered before surgery, which is called neoadjuvant therapy.
The following is a general overview of treatment for stage III breast cancer. Multi-modality treatment, which utilizes two or more treatment techniques, is increasingly recognized as an important approach for improving a patient's chance of cure or prolonging survival. In some cases, participation in a clinical trial utilizing new, innovative therapies may provide the most promising treatment. Circumstances unique to each patient's situation may influence how these general treatment principles are applied. The potential benefits of multi-modality care, participation in a clinical trial, or standard treatment must be carefully balanced with the potential risks. The information on this website is intended to help educate patients about their treatment options and to facilitate a mutual or shared decision-making process with their cancer physician.
Local Therapy: Surgery and Radiation
Systemic Therapy
- Chemotherapy
- Hormonal Therapy
- Targeted Therapy
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